3^rd International Conference on
Toxicology and Clinical Toxicology

Dr. Trosko was Summa Cum Laude, CMU (1956), was a NDEA Predoctoral Fellow, from 1960-63, at Oak Ridge National Lab, and was a Postdoctoral Fellow from 1963-64. He also was an American Cancer Society, Postdoctoral Fellow from 1965 to 66. He received the Teacher-Scholar Award from MSU in 1970, the NCI-Research Career Development Award from 1972-to 77, the Searle Award from U.K. Environmental Mutagen Society in 1979 and the Sigma Xi Senior Scientist Award in 1985. He was honored with the MSU Distinguished Faculty Award in 1987 and the Scientific Achievement Award from the Society of Toxicology in 2001. In 2002, he received the Distinguished Alumni Award, Central Michigan University, for academic teaching and research. He recently received the 2006 "Brain Pool" award, from the Korean Ministry of Science and Technology, Seoul National University, for Adult Stem Cell Research. This award has allowed him to spend three months at Seoul National University, August-October, 2006, to identify adult cancer stem cell markers. More recently, Dr. Trosko has received a Korean Ministry of Education, Science and Technology “World Class University” award to do research at Seoul National University as an Invited Research Professor on human adult stem cells for two months during 2010 & 2011.

The Trosko lab focused on the mechanisms of carcinogenesis and mutagenesis. His initial research involved the study of radiation-induced mammalian mutagenesis. This led to the discovery of deoxyribonucleic acid (DNA) repair in normal human cells and the lack of DNA repair and increased mutagenesis in the cancer-prone xeroderma pigmentosum syndrome. Later work with the tumor promoter, phorbolester, he discovered that the inhibition by tumor-promoting chemicals, oncogenes and growth factors were related to the mechanism of tumor promotion by their shared ability to modulate gap junction function. His team then developed several in vitro assays to detect chemical modulators of gap junctional intercellular communication (GJIC) (e.g., metabolic cooperation assays; fluorescent recovery after photobleaching; scrape loading dye transfer, etc.) Later they found that modulation of GJIC was related to chemical induced teratogenesis, reproductive dysfunction and neurotoxicity. Most recently, his group demonstrated that normal human epithelial stem cells could be isolated from kidney tissues and breast tissues. In addition, anti-tumor chemicals, as well as tumor suppressor genes appear to up-regulate GJIC in a manner opposite to tumor promoters and oncogenes. He has recently discovered biomarkers for adult human stem cells that has provided strong evidence for the "stem cell theory" of cancer.

Professor Kattesh V. Katti is internationally recognized as a leader in the interconnecting fields of—chemistry, radiopharmaceutical sciences, nanotechnology/green nanotechnology and nanomedicine—for biomedical applications, specifically for molecular imaging and therapy of living subjects. The impact of Dr. Katti’s work is widespread, as his pioneering discoveries and strategies, originally developed in his laboratory in bioconjugate chemistry and Nanomedicine, and green nanotechnological tools, are used in many laboratories, industries and hospitals around the world. His contributions in nano and green nanotechnologies have already created a transformative progress in nanomedicine by aiding molecular imaging to help diagnose and manage therapy—all at the cellular levels. Dr. Katti’s ground breaking discoveries in green nanotechnology where he has demonstrated that biocompatible nanoparticles can be produced without the intervention of any toxic chemicals, through phytochemicals of high antioxidant capacities and tumor receptor specificities have created a new generation of molecular imaging and therapeutic nanoceuticals. His approach to green nanotechnology has furthered the scope of holistic and integrative medicine with implications in modulating signaling pathways allowing optimization of therapies targeted to tumor cells/regions without causing adverse toxic effects to normal cells. These original discoveries are expected to have a major impact on how molecular imaging and therapies will eventually be individualized to allow their greater success through theranostic approaches using radioactive nanoparticles, photothermal therapy using targeted nanoparticles and novel therapies involving phytochemicals. Myriad of such approaches developed by Dr. Katti are already impacting clinical translation through comparative oncology in realistic ways as new drugs are being validated for their efficacy in imaging and therapy using tumor bearing dogs where the disease mimics human conditions. In recognition of his original contributions, Dr. Katti has been awarded a number of international awards and citations which include: International Hevesy Medal Award (2015) for excellence in Nuclear Sciences; Elected to the fellowship of the National Academy of Inventors (2015); One of the ‘25 Most Influential Scientists In Molecular Imaging in the World’ award by RT Image, the ‘Father of Green Nanotechnology’ citation by the Nobel Prize Winner Norman Borlaug, Gauss Professorship—Hall of Fame—from the Gottingen Academy of Sciences, ‘Outstanding Scientists Fellows’ award and induction as a Fellow of the Academy of Science, St Louis—one of the oldest scientific academies of the world and many more. In 2013, Dr. Katti was elected as a fellow of the American Association for the Advancement of Science with a citation “for distinguished contributions encompassing nanoscale chemistry, particularly for ground breaking discoveries enabling application of nanotechnology concepts for biomedical applications”. His unprecedented discovery of the production of tumor specific gold nanoparticles through 100% green processes have been cited as the Editor’s choice in Nature, Future Medicine, in Science (AAAS), in Popular Science, by the Discovery Channel and have been highlighted in scientific/medical programs of the British Broadcasting Corporation (BBC, London)

Professor Kattesh V. Katti is internationally recognized as a leader in the interconnecting fields of—chemistry, radiopharmaceutical sciences, nanotechnology/green nanotechnology and nanomedicine—for biomedical applications, specifically for molecular imaging and therapy of living subjects. The impact of Dr. Katti’s work is widespread, as his pioneering discoveries and strategies, originally developed in his laboratory in bioconjugate chemistry and Nanomedicine, and green nanotechnological tools, are used in many laboratories, industries and hospitals around the world. His contributions in nano and green nanotechnologies have already created a transformative progress in nanomedicine by aiding molecular imaging to help diagnose and manage therapy—all at the cellular levels. Dr. Katti’s ground breaking discoveries in green nanotechnology where he has demonstrated that biocompatible nanoparticles can be produced without the intervention of any toxic chemicals, through phytochemicals of high antioxidant capacities and tumor receptor specificities have created a new generation of molecular imaging and therapeutic nanoceuticals. His approach to green nanotechnology has furthered the scope of holistic and integrative medicine with implications in modulating signaling pathways allowing optimization of therapies targeted to tumor cells/regions without causing adverse toxic effects to normal cells. These original discoveries are expected to have a major impact on how molecular imaging and therapies will eventually be individualized to allow their greater success through theranostic approaches using radioactive nanoparticles, photothermal therapy using targeted nanoparticles and novel therapies involving phytochemicals. Myriad of such approaches developed by Dr. Katti are already impacting clinical translation through comparative oncology in realistic ways as new drugs are being validated for their efficacy in imaging and therapy using tumor bearing dogs where the disease mimics human conditions. In recognition of his original contributions, Dr. Katti has been awarded a number of international awards and citations which include: International Hevesy Medal Award (2015) for excellence in Nuclear Sciences; Elected to the fellowship of the National Academy of Inventors (2015); One of the ‘25 Most Influential Scientists In Molecular Imaging in the World’ award by RT Image, the ‘Father of Green Nanotechnology’ citation by the Nobel Prize Winner Norman Borlaug, Gauss Professorship—Hall of Fame—from the Gottingen Academy of Sciences, ‘Outstanding Scientists Fellows’ award and induction as a Fellow of the Academy of Science, St Louis—one of the oldest scientific academies of the world and many more. In 2013, Dr. Katti was elected as a fellow of the American Association for the Advancement of Science with a citation “for distinguished contributions encompassing nanoscale chemistry, particularly for ground breaking discoveries enabling application of nanotechnology concepts for biomedical applications”. His unprecedented discovery of the production of tumor specific gold nanoparticles through 100% green processes have been cited as the Editor’s choice in Nature, Future Medicine, in Science (AAAS), in Popular Science, by the Discovery Channel and have been highlighted in scientific/medical programs of the British Broadcasting Corporation (BBC, London)

Dr. Burton Altura is currently serving as Professor of Medicine at New York University School of Medicine, USA

Dr. Burton Altura is currently serving as Professor of Medicine at New York University School of Medicine, USA

At the NCL, Dr. Dobrovolskaia directs characterization related to a nanomaterials' interaction with components of the immune system. She monitors acute/adverse effects of nanoparticles as they relate to the immune system, both in vitro and in animal models. Dr. Dobrovolskaia is also responsible for the development, validation and performance qualification of in vitro and ex vivo assays to support preclinical characterization of nanoparticles, and for monitoring nanoparticle purity from biological contaminants such as bacteria, yeast, mold and endotoxin. Additionally, she leads structure activity relationship studies aimed at identifying the relationship between nanoparticle physicochemical properties and their interaction with macrophages, components of the blood coagulation cascade, and complement systems. Prior to joining the NCL, Dr. Dobrovolskaia worked as a Research Scientist in a GLP laboratory at PPD Development, Inc. in Richmond, VA. She was responsible for the design, development and validation of bioanalytical ligand-binding assays to support pharmacokinetic and toxicity studies in a variety of drug development projects. She received her M.S. degree from the Kazan State University in Russia, her Ph.D. from the N.N. Blokhin Cancer Research Center of the Russian Academy of Medical Sciences in Moscow, Russia, and completed two postdoctoral trainings in immunology at the National Cancer Institute in Frederick, MD and the University of Maryland in Baltimore, MD. Her areas of expertise include cell signaling, innate immunity, immunogenicity and analytical methodology.

Her areas of expertise include cell signaling, innate immunity, immunogenicity and analytical methodology.

Ghulam Ahmad Shakeel Ansari is a Professor in the University of Texas Medical Branch, USA. He received his PhD from Aligarh Muslim University in India and post doctoral fellowship from University of Texas Medical Branch in USA. He has more than 120 publications and has written more than 5 book chapters. He also received many honors and awards.

The University of Texas Medical Branch

Dr Chuanshu Huang is currently Professor, Department of Environmental Medicine;Professor, Department of Biochemistry and Molecular Pharmacology Environmental Medicine Environmental Medicine Deputy Director

Signal transduction involved in cellular function, tumor promotion and nutrient chemo-prevention. Reactive oxygen species (ROS) involved in cellular signaling and cancer development . Molecular mechanism of anti-cancer nutrients; Environment and carcinogenesis; |Signal transduction involved in cellular function, tumor promotion and nutrient chemo-prevention. Reactive oxygen species (ROS) involved in cellular signaling and cancer development . Molecular mechanism of anti-cancer nutrients; Environment and carcinogenesis; |Signal transduction involved in cellular function, tumor promotion and nutrient chemo-prevention. Reactive oxygen species (ROS) involved in cellular signaling and cancer development . Molecular mechanism of anti-cancer nutrients; Environment and carcinogenesis; |Signal transduction involved in cellular function, tumor promotion and nutrient chemo-prevention. Reactive oxygen species (ROS) involved in cellular signaling and cancer development . Molecular mechanism of anti-cancer nutrients; Environment and carcinogenesis;

Amr Amin has completed his PhD at University of Illinois at Chicago, and received a post-doctoral training in the field of molecular genetics at the University of Pennsylvania School of Medicine. He started his academic career at UAE University where he serves now as a Full Professor of Cell Biology. Amr’s research focuses on ways to control cancer, particularly liver cancer. He published many research articles and reviews and serves as reviewer and as an editorial member of many specialized peer-reviewed journals. He is also a member of many specialized societies and the sole recipient of multiple national and international scientific awards.

Biological application of nanotechnology Biological applications of MRI and CT Cancer Biology Cell Biology Preventive medicine

Marcelo L. Larramendy, Ph.D., serves as Professor of Molecular Cell Biology at the School of Natural Sciences and Museum (National University of La Plata, Argentina). Appointed Senior Researcher of the National Scientific and Technological Research Council of Argentina. Former Member of the Executive Committee of the Latin American Association of Environmental Mutagenesis, Teratogenesis and Carcinogenesis. Author of more than 470 contributions, including scientific publications, research communications and conferences worldwide. Recipient of several national and international awards. Prof. Larramendy is a regular Lecturer at the international A. Hollaender Courses organized by the IAEMS and former guest scientist at NIH (USA) and University of Helsinki, (Finland). He is expert in Genetic Toxicology and is, or has been, referee for more than 30 international scientific journals. Member of the International Panel of Experts at the International Agency for Research on Cancer (IARC, WHO, Lyon, France) in 2015 for the evaluation of DDT, 2,4-D and Lindane. Presently, Prof. Dr. Larramendy is Head of the Laboratory of Molecular Cytogenetics and Genotoxicology at the UNLP.

Marcelo L. Larramendy’s fields of research interest include genotoxicity, Teratogenesis and Carcinogenesis. His areas of expertise include Molecular Cytogenetcis, Genetic Toxicology and Ecotoxicology.

Yazen M Alnouti is an Assistant Professor in the Department of Pharmaceutical Sciences, University of Nebraska Medical Center. He worked as a Research Assistant Professor in the Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center. he received his Post Doctorate from University of Kansas Medical Center. He was selected by Selected by “Who’s Who in America” as a scientist with outstanding achievements in the year 2009. He has a Professional membership in American Association of Colleges of Pharmacy (AACP). He experienced as a Teaching & Research Assistant in the College of Pharmacy, University of Georgia. His highlights of Research expertise include Drug Metabolism and Disposition, High-Throughput Bioanalytical Chemistry and Pharmacokinetics.

Application of bioanalytical chemistry, in vitro models such as microsomes and stably-transfected cell lines, and in vivo animal models such as knock-out mice, to support ADMET (absorption, distribution, metabolism, excretion, and toxicity) and pharmacokinetics studies.

Antonietta M. Gatti, Ph.D. is the coordinator of the Italian Institute of Technology's Project of Nanoecotoxicology, called INESE. She is a selected expert of the FAO/WHO for the safety in nanotechnological food, and a Member of the NANOTOX Cluster of the European Commission. She is also the author of a book titled “Nanopathology: the health impact of nanoparticles,” and on the Editorial Board of Journal of Biomaterials Applications and a member of the CPCM of the Italian Ministry of Defense. She also founded a laboratory called Nanodiagnostics for the evaluation of the pathological tissues of patients. She is presently at the University of Modena and Reggio Emilia, Italy.

Biomaterials and Tissue Interface, nanopathology, Nanodiagnostics

Alireza Heidari, Ph.D., D.Sc. is a Full Distinguished Professor and Academic Tenure of Chemistry and also Enrico Fermi Distinguished Chair in Molecular Spectroscopy at California South University (CSU), Irvine, California, USA. He has got his Ph.D. and D.Sc. degrees from California South University (CSU), Irvine, California, USA. Furthermore, he has double postdocs in Project Management, Oncology, Human Cancer Tissues and Synchrotron Radiation from Monash University, Melbourne, Victoria, Australia and also in Nanochemistry and Modern Molecular Electronic–Structure Computations Theory from California South University (CSU), Irvine, California, USA. His research interests include Biophysical Chemistry, Biomolecular Spectroscopy, Quantum Chemistry, Nanochemistry, Modern Electronic Structure Computations, Theoretical Chemistry, Mathematical Chemistry, Computational Chemistry, Vibrational Spectroscopy, Molecular Modelling, Ab initio & Density Functional Methods, Molecular Structure, Biochemistry, Molecular Simulation, Pharmaceutical Chemistry, Medicinal Chemistry, Oncology, Synchrotron Radiation, Synchrocyclotron Radiation, LASER, Anti–Cancer Nano Drugs, Nano Drugs Delivery, ATR–FTIR Spectroscopy, Raman Spectroscopy, Intelligent Molecules, Molecular Dynamics, Biosensors, Biomarkers, Molecular Diagnostics, Numerical Chemistry, Nucleic Acids, DNA/RNA Monitoring, DNA/RNA Hypermethylation & Hypomethylation, Human Cancer Tissues, Human Cancer Cells, Tumors, Cancer Tissues, Cancer Cells, etc. He has participated at more than five hundred reputed international conferences, seminars, congresses, symposiums and forums around the world as yet. Also, he possesses many published articles in Science Citation Index (SCI)/International Scientific Indexing (ISI), Medline/PubMed and Scopus Journals. It should be noted that he has visited many universities or scientific and academic research institutes in different countries such as United States, United Kingdom, Canada, Australia, New Zealand, Scotland, Ireland, Netherlands, Belgium, Denmark, Luxembourg, Romania, Greece, Russia, Estonia, Ukraine, Turkey, France, Swiss, Germany, Sweden, Norway, Italy, Austria, Czech Republic, Hungary, Poland, South Africa, Egypt, Brazil, Spain, Portugal, Mexico, Japan, Singapore, Malaysia, Indonesia, Thailand, Taiwan, Hong Kong, South Korea, China, India, Kingdom of Saudi Arabia, Jordan, Qatar, United Arab Emirates, etc. as research fellow, sabbatical and volunteer researcher or visitor and so on heretofore. He has a history of several years of teaching for college students and various disciplines and trends in different universities. Moreover, he has been a senior advisor in various industry and factories. He is expert in many computer programs and programming languages. Hitherto, he has authored more than twenty books and book chapters in different fields of Chemistry. Syne, he has been awarded more than one thousand reputed international awards, prizes, scholarships and honors. Heretofore, he has multiple editorial duties in many reputed international and peer–reviewed journals, books and publishers. Hitherward, he is a member of more than five hundred reputed international academic–scientific–research institutes around the world. It should be noted that he is currently the President of American International Standards Institute (AISI), Irvine, California, USA and also Director of the BioSpectroscopy Core Research Laboratory at California South University (CSU), Irvine, California, USA.

His research interests include Biophysical Chemistry, Biomolecular Spectroscopy, Quantum Chemistry, Nanochemistry, Modern Electronic Structure Computations, Theoretical Chemistry, Mathematical Chemistry, Computational Chemistry, Vibrational Spectroscopy, Molecular Modelling, Ab initio & Density Functional Methods, Molecular Structure, Biochemistry, Molecular Simulation, Pharmaceutical Chemistry, Medicinal Chemistry, Oncology, Synchrotron Radiation, Synchrocyclotron Radiation, LASER, Anti–Cancer Nano Drugs, Nano Drugs Delivery, ATR–FTIR Spectroscopy, Raman Spectroscopy, Intelligent Molecules, Molecular Dynamics, Biosensors, Biomarkers, Molecular Diagnostics, Numerical Chemistry, Nucleic Acids, DNA/RNA Monitoring, DNA/RNA Hypermethylation & Hypomethylation, Human Cancer Tissues, Human Cancer Cells, Tumors, Cancer Tissues, Cancer Cells, etc.